Opto 22 Headquarters 43044 Business Park Drive Temecula, CA 92590-3614 Phone: 951-695-3000 Toll Free (in the U.S.): 800-321-6786 Opto 22 headquarters are located in Temecula, California. San Diego is about an hour to the south, and Los Angeles is about two hours to the northwest. See accommodations near Opto 22.